The COVID-19 pandemic is a severe ongoing health crisisworldwide. Studying the socio-economic impacts of COVID-19 can help policymakers develop successful pandemic management plans. This paper focuses on the spatial epidemiology of COVID-19 among different social classes in the Kermanshah metropolis, Iran. This cross-sectional study uses the data of people infected with COVID-19 in the Kermanshah metropolis in 2020, acquired from the official COVID-19 Registry of Kermanshah. The results show that 2013 people were infected with COVID-19 (male = 1164 and female = 849). The mean age of the patients was 45 ± 18.69. The Moran’s I show that COVID-19 in different social classes was clustered across the neighbourhoods in the Kermanshah metropolis. The mean ages of men and women were 44.51 ± 18.62 and 45.69 ± 18.76, respectively. Importantly, COVID-19 was highly prevalent in the middle-class groups. Age group comparisons indicate that older people were the most infected in poorer neighbourhoods. In the middle-classtheage group of 0–14 years and in the rich neighbourhoods the age group of 15–64 years were the most exposed to the disease. The findings of this study suggest that older people and lower socioeconomic classes should be prioritised while developing and implementing preventative programs for COVID-19 and similar pandemics.